Wound, Ostomy and Continence Nurses Society (WOCN) Practice Exam

What role do protease inhibitors play in wound healing?

1. They enhance granulation tissue formation.

2. They upregulate proinflammatory MMPs.

3. They downregulate proinflammatory MMPs.

4. They improve blood circulation to the wound site.

The correct answer is: They downregulate proinflammatory MMPs.

Protease inhibitors play a critical role in wound healing by downregulating proinflammatory matrix metalloproteinases (MMPs). MMPs are enzymes that degrade components of the extracellular matrix, which is essential for maintaining the structural integrity of tissues during the healing process. When these proinflammatory MMPs are present in excessive amounts, they can lead to impaired healing by breaking down granulation tissue and delaying the formation of new tissue. By inhibiting these MMPs, protease inhibitors can help maintain a balanced environment conducive to wound healing. This action promotes the stability of the extracellular matrix, which enhances the formation of granulation tissue and allows for proper tissue repair. Understanding this mechanism is vital for developing effective wound care strategies and interventions for patients with chronic wounds or impaired healing responses.